Please use this identifier to cite or link to this item:
https://t2-4.bsc.es/jspui/handle/123456789/60145Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Cunliffe, V, University of Sheffield | en |
| dc.date | 2019-01-04T00:00:00Z | en |
| dc.identifier | 10.5255/UKDA-SN-853521 | - |
| dc.identifier | 853521 | - |
| dc.identifier | https://doi.org/10.5255/UKDA-SN-853521 | - |
| dc.identifier.uri | https://t2-4.bsc.es/jspui/handle/123456789/60145 | * |
| dc.description | Dysregulation of the Hypothalamo-Pituitary-Adrenal (HPA) Axis is a characteristic feature of the pathophysiology of depression, anxiety and post-traumatic stress disorder (PTSD), which result from chronic or extreme exposures to psychosocial stressors. A zebrafish mutant lacking Glucocorticoid Receptor (GR) function exhibits profound behavioural and endocrine abnormalities caused by chronic, persistent HPA axis dysregulation. To identify the glucocorticoid-sensitive methylation signature within the brain methylome, we performed a comparative analysis of wild-type and GR mutant adult brain samples using Whole Genome Bisulfite Sequencing (WGBS). The results of this analysis are deposited in the NCBO GEO database. <p>The social environments in which we live provide daily challenges that affect how we think and feel, influencing our behaviour and sense of well-being. However, it is far from clear exactly how these experiences affect us at a physical level. Recent research in biology has discovered molecules that are found in all of our cells, which interpret our experiences by switching genes on or off in particular cell types. These molecules, or 'epigenetic' mechanisms, bind to DNA and control gene activity, which in turn change the functions of our cells, tissues and organs, and so affect what we think, feel and do. We are beginning to understand that these epigenetic mechanisms are modified by factors that also affect our health, and recent evidence indicates that social stress is one such factor. Societies in which there is a bigger gap between rich and poor, such as the UK, also have bigger, more stressful social and health inequalities. Good evidence suggests that the social stress caused by social inequality leads to ill-health and that this link may involve epigenetic mechanisms. This project aims to build a network of biological and social scientists to explore how social stress causes epigenetic changes which affect biology and behaviour. To address this problem, we will establish a team with wide-ranging expertise in investigating (a) the physical effects of stress on gene activity in the brain and the body, (b) the impacts of social inequality on health, and (c) how we think about the way our experiences get under our skin to shape behaviour and well-being. This team of social science, public health and biology researchers, will develop and carry out novel shared projects. We will hold discussion meetings to consider new biological and sociological ideas together, and share new discoveries that will help to explain how social stresses exert their effects on the brain and the rest of the body, and the roles of epigenetics in these processes. We will also meet with industrial, government and health service professionals, to consider the potential impacts of our research for their work, and engage with the general public more broadly to discuss the wider implications of this research for society.</p> | en |
| dc.language | en | - |
| dc.rights | Vincent Cunliffe, University of Sheffield | en |
| dc.subject | EPIGENETICS | en |
| dc.subject | DNA METHYLATION | en |
| dc.subject | GLUCOCORTICOID SIGNALLING | en |
| dc.subject | ZEBRAFISH | en |
| dc.subject | BRAIN | en |
| dc.subject | 2019 | en |
| dc.title | Gene expression omnibus: A biosocial systems approach to understanding the epigenetic embedding of social stress responses 2015-2018 | en |
| dc.type | Dataset | en |
| dc.coverage | United Kingdom | en |
| Appears in Collections: | Cessda | |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.